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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| CC Sabathia | 2015-2015 | .000 | 0 | 0 | 12 | 13 | 0 | 5.37 | 108 |
| Blake Sabol | 2024-2025 | .237 | 3 | 30 | 0 | 0 | 0 | 0.00 | 0 |
| Fernando Salas | 2015-2015 | .000 | 0 | 0 | 1 | 1 | 0 | 2.74 | 12 |
| Danny Salazar | 2015-2015 | .000 | 0 | 0 | 0 | 0 | 2 | 3.27 | 12 |
| Raúl Salazar | 2022-2022 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Sale | 2015-2025 | .000 | 0 | 0 | 155 | 99 | 0 | 3.18 | 2122 |
| Jarrod Saltalamacchia | 2015-2015 | .225 | 0 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Jeff Samardzija | 2015-2021 | .122 | 1 | 4 | 56 | 76 | 1 | 4.72 | 970 |
| Keyvius Sampson | 2016-2022 | .000 | 0 | 0 | 20 | 13 | 12 | 3.39 | 384 |
| Aaron Sanchez | 2015-2018 | .000 | 0 | 0 | 34 | 45 | 1 | 4.49 | 488 |
| Alec Sanchez | 2023-2025 | .224 | 12 | 91 | 0 | 0 | 0 | 0.00 | 0 |
| Alexquemer Sanchez | 2023-2024 | .145 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Anibal Sanchez | 2015-2017 | .000 | 0 | 0 | 13 | 23 | 0 | 4.85 | 184 |
| Gary Sanchez | 2018-2021 | .213 | 15 | 70 | 0 | 0 | 0 | 0.00 | 0 |
| Hector Sanchez | 2018-2018 | .244 | 0 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Jesus B. Sanchez | 2022-2024 | .209 | 1 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Manny Sanchez | 2021-2025 | .242 | 132 | 355 | 0 | 0 | 0 | 0.00 | 0 |
| Ricardo Sanchez | 2021-2025 | .000 | 0 | 0 | 57 | 50 | 0 | 4.11 | 731 |
| Cord Sandberg | 2021-2025 | .248 | 42 | 209 | 0 | 0 | 0 | 0.00 | 0 |
| Pablo Sandoval | 2016-2020 | .270 | 56 | 283 | 0 | 0 | 0 | 0.00 | 0 |
| Cole Sands | 2023-2025 | .000 | 0 | 0 | 9 | 7 | 3 | 3.57 | 196 |
| Miguel Sano | 2015-2025 | .206 | 214 | 552 | 0 | 0 | 0 | 0.00 | 0 |
| Saturnino Santa Cruz | 2025-2025 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 1 |
| Carlos Santana | 2015-2022 | .218 | 110 | 419 | 0 | 0 | 0 | 0.00 | 0 |
| Christophers Santana | 2023-2025 | .000 | 0 | 0 | 7 | 6 | 5 | 3.75 | 161 |
| Domingo Santana | 2017-2018 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Ervin Santana | 2015-2015 | .000 | 0 | 0 | 8 | 5 | 0 | 5.49 | 68 |
| Benito Santiago Jr. | 2023-2025 | .289 | 6 | 46 | 0 | 0 | 0 | 13.50 | 1 |
| Luis Sardinas | 2016-2021 | .241 | 4 | 77 | 0 | 0 | 0 | 0.00 | 0 |
| Michael Saunders | 2016-2016 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Joey Savin | 2020-2020 | .333 | 0 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Lou Schaefer | 2023-2025 | .269 | 14 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Scott Schebler | 2015-2016 | .242 | 8 | 42 | 0 | 0 | 0 | 0.00 | 0 |
| Alex Scherff | 2024-2025 | .000 | 0 | 0 | 1 | 2 | 2 | 2.59 | 73 |
| Max Scherzer | 2015-2021 | .000 | 0 | 0 | 87 | 64 | 0 | 4.09 | 1064 |
| Jonathan Schoop | 2017-2025 | .234 | 137 | 468 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Schwarber | 2015-2025 | .240 | 162 | 516 | 0 | 0 | 0 | 0.00 | 0 |
| J.J. Schwarz | 2023-2025 | .231 | 21 | 79 | 0 | 0 | 0 | 0.00 | 0 |
| Ken Scorziello | 2025-2025 | .247 | 10 | 26 | 0 | 0 | 0 | 0.00 | 0 |
| Levi Scott | 2020-2021 | .213 | 2 | 7 | 0 | 0 | 0 | 0.00 | 0 |
| Evan Scribner | 2015-2021 | .000 | 0 | 0 | 33 | 28 | 28 | 2.59 | 599 |
| Corey Seager | 2016-2025 | .297 | 229 | 816 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Seager | 2015-2024 | .227 | 96 | 396 | 0 | 0 | 0 | 0.00 | 0 |
| Tom Seaver | 2025-2025 | .000 | 0 | 0 | 1 | 0 | 0 | 4.08 | 16 |
| Hunter Seay | 2021-2022 | .201 | 3 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Jean Segura | 2015-2020 | .251 | 28 | 190 | 0 | 0 | 0 | 0.00 | 0 |
| Marcus Semien | 2016-2025 | .197 | 9 | 52 | 0 | 0 | 0 | 0.00 | 0 |
| Antonio Senzatela | 2020-2020 | .000 | 0 | 0 | 0 | 0 | 0 | 3.86 | 3 |
| Daniel Seres | 2020-2025 | .257 | 14 | 50 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Serrano | 2022-2025 | .000 | 0 | 0 | 32 | 37 | 0 | 4.95 | 403 |
| Hemerson Serven | 2023-2023 | .205 | 3 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Luis Severino | 2016-2025 | .000 | 0 | 0 | 14 | 13 | 3 | 5.48 | 145 |
| Richie Shaffer | 2015-2020 | .167 | 4 | 23 | 0 | 0 | 0 | 0.00 | 0 |
| Colton Shaver | 2020-2025 | .220 | 7 | 27 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Shaw | 2018-2025 | .244 | 3 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Justus Sheffield | 2022-2024 | .000 | 0 | 0 | 9 | 2 | 2 | 4.11 | 137 |
| Cam Shepherd | 2023-2025 | .246 | 36 | 127 | 0 | 0 | 0 | 0.00 | 0 |
| Jimmie Sherfy | 2018-2021 | .000 | 0 | 0 | 4 | 7 | 5 | 5.34 | 37 |
| Zach Sherman | 2023-2025 | .250 | 1 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Cason Sherrod | 2024-2025 | .000 | 0 | 0 | 9 | 9 | 28 | 2.95 | 161 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| James Shields | 2015-2016 | .000 | 0 | 0 | 11 | 16 | 1 | 3.90 | 154 |
| Chasen Shreve | 2016-2024 | .000 | 0 | 0 | 16 | 12 | 8 | 3.74 | 310 |
| Nick Shumpert | 2020-2025 | .223 | 9 | 45 | 0 | 0 | 0 | 0.00 | 0 |
| José Sierra | 2024-2025 | .000 | 0 | 0 | 1 | 1 | 1 | 3.65 | 39 |
| José Silva | 2024-2024 | .000 | 0 | 0 | 0 | 0 | 1 | 2.70 | 4 |
| Andrelton Simmons | 2015-2021 | .239 | 36 | 219 | 0 | 0 | 0 | 0.00 | 0 |
| Shae Simmons | 2015-2025 | .000 | 0 | 0 | 39 | 43 | 27 | 3.08 | 1012 |
| John Simms | 2018-2024 | .000 | 0 | 0 | 12 | 9 | 7 | 4.34 | 247 |
| Brady Singer | 2021-2025 | .000 | 0 | 0 | 27 | 38 | 0 | 4.56 | 420 |
| Jon Singleton | 2018-2020 | .212 | 21 | 58 | 0 | 0 | 0 | 0.00 | 0 |
| Mike Singleton | 2022-2022 | .273 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Tyler Skaggs | 2018-2025 | .000 | 0 | 0 | 18 | 16 | 2 | 3.98 | 288 |
| Ethan Skender | 2018-2018 | .167 | 1 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Joe Skinner | 2025-2025 | .400 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Elijah Skipps | 2021-2025 | .302 | 2 | 8 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Skipworth | 2016-2022 | .214 | 32 | 122 | 0 | 0 | 0 | 0.00 | 0 |
| Aaron Slegers | 2019-2025 | .000 | 0 | 0 | 87 | 61 | 0 | 3.73 | 934 |
| Ethan Small | 2022-2025 | .000 | 0 | 0 | 14 | 19 | 1 | 4.45 | 317 |
| Austin Smith | 2024-2024 | .000 | 0 | 0 | 0 | 0 | 0 | 10.57 | 9 |
| Caleb Smith | 2022-2024 | .000 | 0 | 0 | 0 | 1 | 0 | 5.84 | 8 |
| Carson Smith | 2015-2022 | .000 | 0 | 0 | 21 | 9 | 6 | 3.56 | 341 |
| Drew Smith | 2025-2025 | .000 | 0 | 0 | 0 | 1 | 1 | 7.11 | 16 |
| Joe Smith | 2016-2016 | .000 | 0 | 0 | 1 | 1 | 0 | 6.23 | 12 |
| Mallex Smith | 2015-2025 | .249 | 61 | 376 | 0 | 0 | 0 | 0.00 | 0 |
| Seth Smith | 2015-2015 | .287 | 4 | 35 | 0 | 0 | 0 | 0.00 | 0 |
| Steve Smith | 2022-2025 | .265 | 64 | 215 | 0 | 0 | 0 | 0.00 | 0 |
| Will Smith | 2015-2024 | .000 | 0 | 0 | 10 | 16 | 17 | 4.72 | 253 |
| Justin Smoak | 2015-2015 | .220 | 0 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Drew Smyly | 2015-2023 | .000 | 0 | 0 | 77 | 74 | 4 | 4.53 | 906 |
| Blake Snell | 2019-2025 | .000 | 0 | 0 | 23 | 17 | 4 | 3.23 | 317 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Jorge Soler | 2015-2022 | .254 | 117 | 415 | 0 | 0 | 0 | 0.00 | 0 |
| Joakim Soria | 2015-2018 | .000 | 0 | 0 | 10 | 10 | 5 | 4.57 | 123 |
| Rafael Soriano | 2015-2015 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 2 |
| Sammy Sosa | 2025-2025 | .056 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Fredderi Soto | 2022-2025 | .000 | 0 | 0 | 9 | 3 | 0 | 4.70 | 172 |
| Isael Soto | 2019-2019 | .222 | 1 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Steven Souza Jr. | 2015-2023 | .236 | 99 | 329 | 0 | 0 | 0 | 0.00 | 0 |
| Logan Sowers | 2024-2025 | .267 | 2 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Denard Span | 2015-2015 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Tris Speaker | 2020-2025 | .336 | 49 | 359 | 0 | 0 | 0 | 0.00 | 0 |
| Tremaine Spears | 2020-2025 | .240 | 58 | 244 | 0 | 0 | 0 | 0.00 | 0 |
| Alex Speas | 2025-2025 | .000 | 0 | 0 | 7 | 3 | 0 | 3.61 | 102 |
| Nick Sprengel | 2020-2025 | .000 | 0 | 0 | 25 | 31 | 6 | 4.14 | 504 |
| George Springer | 2015-2024 | .215 | 200 | 560 | 0 | 0 | 0 | 0.00 | 0 |
| Jeff Stafford | 2025-2025 | .000 | 0 | 0 | 4 | 4 | 2 | 4.72 | 66 |
| Craig Stammen | 2015-2016 | .000 | 0 | 0 | 5 | 5 | 29 | 3.04 | 96 |
| Chris Stanley | 2025-2025 | .130 | 0 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Giancarlo Stanton | 2015-2025 | .251 | 391 | 1054 | 0 | 0 | 0 | 0.00 | 0 |
| Bubba Starling | 2022-2022 | .097 | 1 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Max Stassi | 2016-2025 | .244 | 258 | 684 | 0 | 0 | 0 | 0.00 | 0 |
| Josh Staumont | 2020-2025 | .000 | 0 | 0 | 39 | 49 | 90 | 3.98 | 499 |
| Robert Stephenson | 2016-2022 | .000 | 0 | 0 | 1 | 2 | 0 | 4.13 | 23 |
| Tyler Stephenson | 2024-2025 | .204 | 5 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Dan Stevens | 2022-2025 | .000 | 0 | 0 | 30 | 20 | 137 | 2.88 | 372 |
| Christin Stewart | 2022-2024 | .277 | 39 | 113 | 0 | 0 | 0 | 0.00 | 0 |
| D.J. Stewart | 2018-2025 | .279 | 14 | 105 | 0 | 0 | 0 | 0.00 | 0 |
| Kohl Stewart | 2021-2025 | .000 | 0 | 0 | 3 | 4 | 1 | 4.09 | 95 |
| Jake Stinnett | 2023-2023 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 7 |
| Robby Stone | 2020-2025 | .000 | 0 | 0 | 56 | 35 | 0 | 3.82 | 792 |
| Drew Storen | 2015-2025 | .000 | 0 | 0 | 49 | 44 | 102 | 4.11 | 634 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Trevor Story | 2018-2019 | .250 | 3 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Nicholas Storz | 2023-2025 | .000 | 0 | 0 | 21 | 26 | 13 | 4.93 | 319 |
| Stephen Strasburg | 2015-2021 | .200 | 0 | 0 | 79 | 72 | 0 | 3.69 | 1156 |
| Huston Street | 2015-2023 | .000 | 0 | 0 | 34 | 15 | 12 | 3.55 | 542 |
| Ross Stripling | 2019-2019 | .000 | 0 | 0 | 0 | 3 | 0 | 5.35 | 26 |
| Marcus Stroman | 2015-2025 | .000 | 0 | 0 | 142 | 105 | 0 | 3.62 | 1659 |
| Pedro Strop | 2015-2018 | .000 | 0 | 0 | 13 | 7 | 4 | 3.69 | 262 |
| Chase Strumpf | 2023-2025 | .193 | 9 | 39 | 0 | 0 | 0 | 0.00 | 0 |
| Eugenio Suarez | 2018-2024 | .250 | 29 | 143 | 0 | 0 | 0 | 0.00 | 0 |
| Jose A. Suarez | 2021-2025 | .000 | 0 | 0 | 2 | 7 | 0 | 4.78 | 88 |
| Colby Suggs | 2017-2025 | .000 | 0 | 0 | 0 | 1 | 1 | 4.84 | 25 |
| Toshihiro Sugiura | 2025-2025 | .000 | 0 | 0 | 0 | 0 | 0 | 6.75 | 2 |
| Andrew Susac | 2018-2024 | .230 | 34 | 138 | 0 | 0 | 0 | 0.00 | 0 |
| Ichiro Suzuki | 2015-2015 | .324 | 0 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Kurt Suzuki | 2015-2015 | .235 | 1 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Shota Suzuki | 2022-2025 | .000 | 0 | 0 | 23 | 18 | 0 | 5.00 | 329 |
| Dansby Swanson | 2020-2025 | .266 | 45 | 275 | 0 | 0 | 0 | 0.00 | 0 |
| Blake Swihart | 2015-2021 | .269 | 59 | 290 | 0 | 0 | 0 | 0.00 | 0 |
| Nick Swisher | 2015-2015 | .271 | 6 | 22 | 0 | 0 | 0 | 0.00 | 0 |
| Noah Syndergaard | 2015-2025 | .000 | 0 | 0 | 119 | 97 | 0 | 4.05 | 1724 |
| Matt Szczur | 2017-2017 | .190 | 0 | 2 | 0 | 0 | 0 | 0.00 | 0 |
