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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Chris Sale# | 263.0 | 2015 | |
| 2 | Jose Fernandez# | 261.0 | 2019 | |
| 3 | Jose Fernandez# | 260.0 | 2018 | |
| 4 | Clayton Kershaw# | 253.0 | 2016 | |
| 4 | Clayton Kershaw# | 253.0 | 2015 | |
| 6 | Sonny Gray# | 250.0 | 2019 | |
| 7 | Jose Fernandez# | 248.0 | 2017 | |
| 7 | Adam Wainwright | 248.0 | 2016 | |
| 7 | Adam Wainwright | 248.0 | 2015 | |
| 10 | Corey Kluber | 247.0 | 2021 | |
| 11 | Cole Hamels | 244.0 | 2015 | |
| 12 | Jose Fernandez# | 243.0 | 2020 | |
| 13 | Zack Greinke | 242.0 | 2017 | |
| 14 | Chris Sale# | 240.0 | 2018 | |
| 14 | Masahiro Tanaka | 240.0 | 2018 | |
| 14 | Garrett Richards | 240.0 | 2015 | |
| 17 | Masahiro Tanaka | 239.0 | 2017 | |
| 17 | Max Scherzer | 239.0 | 2017 | |
| 19 | Chris Sale# | 237.0 | 2017 | |
| 19 | Stephen Strasburg | 237.0 | 2018 | |
| 21 | Masahiro Tanaka | 236.0 | 2016 | |
| 22 | Marcus Stroman# | 235.0 | 2020 | |
| 23 | Chris Sale# | 234.0 | 2019 | |
| 24 | Kensaku Yamaguchi# | 233.0 | 2025 | |
| 24 | Garrett Richards | 233.0 | 2016 | |
| 26 | Madison Bumgarner# | 232.0 | 2018 | |
| 26 | Jordan Zimmermann | 232.0 | 2016 | |
| 26 | Chris Sale# | 232.0 | 2020 | |
| 29 | Stephen Strasburg | 231.0 | 2015 | |
| 29 | Sonny Gray# | 231.0 | 2020 | |
| 31 | Shelby Miller# | 230.0 | 2018 | |
| 31 | Kolby Allard# | 230.0 | 2021 | |
| 33 | Alex Reyes# | 229.0 | 2023 | |
| 33 | Marcus Stroman# | 229.0 | 2016 | |
| 33 | Chris Sale# | 229.0 | 2022 | |
| 36 | Adam Conley# | 228.0 | 2019 | |
| 36 | Masahiro Tanaka | 228.0 | 2019 | |
| 36 | Cole Hamels | 228.0 | 2018 | |
| 39 | David Price | 227.0 | 2015 | |
| 39 | Cole Hamels | 227.0 | 2016 | |
| 41 | Jordan Zimmermann | 226.0 | 2019 | |
| 41 | Alex Reyes# | 226.0 | 2021 | |
| 41 | Clayton Kershaw# | 226.0 | 2020 | |
| 41 | Jose Fernandez# | 226.0 | 2022 | |
| 45 | Matt Wisler# | 225.0 | 2019 | |
| 45 | Stephen Strasburg | 225.0 | 2019 | |
| 47 | Felix Hernandez | 224.0 | 2015 | |
| 47 | Masahiro Tanaka | 224.0 | 2021 | |
| 47 | Julio Teheran# | 224.0 | 2021 | |
| 47 | Alex Wood# | 224.0 | 2016 | |
| 47 | Jon Lester | 224.0 | 2015 | |
| 52 | Alex Wood# | 223.0 | 2020 | |
| 52 | Felix Hernandez | 223.0 | 2016 | |
| 54 | Matt Wisler# | 222.0 | 2021 | |
| 54 | Masahiro Tanaka | 222.0 | 2020 | |
| 54 | Cliff Lee | 222.0 | 2015 | |
| 57 | Cole Hamels | 221.0 | 2019 | |
| 57 | David Price | 221.0 | 2016 | |
| 57 | Jacob deGrom | 221.0 | 2016 | |
| 57 | Shelby Miller# | 221.0 | 2019 | |
| 61 | Clayton Kershaw# | 220.0 | 2023 | |
| 61 | Stephen Strasburg | 220.0 | 2017 | |
| 61 | Julio Teheran# | 220.0 | 2022 | |
| 61 | Alex Wood# | 220.0 | 2019 | |
| 65 | Marcus Stroman# | 218.0 | 2015 | |
| 65 | Masahiro Tanaka | 218.0 | 2015 | |
| 65 | Carlos Rodon# | 218.0 | 2020 | |
| 65 | David Price | 218.0 | 2017 | |
| 65 | Corey Kluber | 218.0 | 2015 | |
| 65 | Garrett Richards | 218.0 | 2018 | |
| 65 | Jake Arrieta | 218.0 | 2015 | |
| 72 | Clayton Kershaw# | 217.0 | 2017 | |
| 72 | Sonny Gray# | 217.0 | 2016 | |
| 72 | Matt Wisler# | 217.0 | 2017 | |
| 72 | Hyun-jin Ryu# | 217.0 | 2015 | |
| 72 | Julio Teheran# | 217.0 | 2020 | |
| 72 | Ben Jordan# | 217.0 | 2024 | |
| 72 | Sonny Gray# | 217.0 | 2017 | |
| 72 | Matt Wisler# | 217.0 | 2020 | |
| 72 | Corey Kluber | 217.0 | 2016 | |
| 72 | Grant Holmes# | 217.0 | 2020 | |
| 72 | Aaron Slegers# | 217.0 | 2023 | |
| 83 | Jeff Samardzija | 216.0 | 2019 | |
| 83 | Masahiro Tanaka | 216.0 | 2022 | |
| 83 | Zack Greinke | 216.0 | 2016 | |
| 83 | Alex Wood# | 216.0 | 2017 | |
| 83 | Shelby Miller# | 216.0 | 2017 | |
| 83 | Eduardo Rodriguez# | 216.0 | 2025 | |
| 83 | Hyun-jin Ryu# | 216.0 | 2025 | |
| 83 | Jarred Cosart | 216.0 | 2016 | |
| 91 | Aaron Nola# | 215.0 | 2022 | |
| 91 | Takahiro Norimoto# | 215.0 | 2021 | |
| 91 | Max Scherzer | 215.0 | 2019 | |
| 91 | Justin Verlander | 215.0 | 2019 | |
| 95 | Kensaku Yamaguchi# | 214.0 | 2024 | |
| 95 | Shelby Miller# | 214.0 | 2016 | |
| 97 | Johnny Cueto | 213.0 | 2015 | |
| 97 | Ian Kennedy | 213.0 | 2016 | |
| 97 | Homer Bailey | 213.0 | 2015 | |
| 97 | Jake Thompson# | 213.0 | 2020 |
