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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Chris Sale# | 2402.0 | 2015-2025 | |
| 2 | Marcus Stroman# | 2177.2 | 2015-2025 | |
| 3 | Shelby Miller# | 2110.2 | 2015-2025 | |
| 4 | Alex Wood# | 2043.1 | 2015-2025 | |
| 5 | Clayton Kershaw# | 2025.2 | 2015-2025 | |
| 6 | Jose Fernandez# | 2010.1 | 2015-2025 | |
| 7 | Matt Wisler# | 2006.0 | 2016-2025 | |
| 8 | Julio Teheran# | 1999.1 | 2015-2025 | |
| 9 | Masahiro Tanaka | 1989.2 | 2015-2024 | |
| 10 | Noah Syndergaard# | 1940.1 | 2015-2025 | |
| 11 | Sonny Gray# | 1929.1 | 2015-2025 | |
| 12 | Yordano Ventura# | 1776.0 | 2016-2025 | |
| 13 | Zack Wheeler# | 1635.1 | 2015-2024 | |
| 14 | Aaron Nola# | 1553.0 | 2015-2025 | |
| 15 | Grayson Garvin# | 1543.0 | 2017-2025 | |
| 16 | Carlos Rodon# | 1532.1 | 2018-2025 | |
| 17 | Cole Hamels | 1517.1 | 2015-2022 | |
| 18 | Michael Wacha# | 1484.0 | 2015-2025 | |
| 19 | Grant Holmes# | 1461.1 | 2018-2025 | |
| 20 | Jerad Eickhoff# | 1460.0 | 2016-2025 | |
| 21 | Corey Kluber | 1443.2 | 2015-2024 | |
| 22 | Jeurys Familia | 1420.2 | 2015-2025 | |
| 23 | Garrett Richards | 1401.0 | 2015-2022 | |
| 24 | Jacob deGrom | 1363.0 | 2015-2022 | |
| 25 | Madison Bumgarner# | 1340.2 | 2015-2022 | |
| 26 | Jake Thompson# | 1301.1 | 2018-2025 | |
| 27 | Aaron Slegers# | 1292.2 | 2019-2025 | |
| 28 | Danny Duffy | 1273.0 | 2015-2023 | |
| 29 | Nate Karns | 1266.0 | 2015-2023 | |
| 30 | Max Scherzer | 1263.2 | 2015-2021 | |
| 31 | Stephen Strasburg | 1260.0 | 2015-2021 | |
| 32 | Chris Beck# | 1238.0 | 2018-2025 | |
| 33 | Drew Smyly | 1211.0 | 2015-2023 | |
| 34 | Jose Urena# | 1202.2 | 2018-2025 | |
| 35 | Alex Reyes# | 1199.0 | 2020-2025 | |
| 36 | Jordan Zimmermann | 1197.0 | 2015-2020 | |
| 37 | Kyle Hendricks# | 1194.0 | 2015-2025 | |
| 38 | Kolby Allard# | 1168.2 | 2020-2025 | |
| 39 | Jeff Samardzija | 1166.2 | 2015-2021 | |
| 40 | Felix Hernandez | 1152.2 | 2015-2021 | |
| 41 | Justin Verlander | 1151.1 | 2015-2020 | |
| 42 | Mike Foltynewicz# | 1147.2 | 2015-2025 | |
| 43 | David Price | 1138.1 | 2015-2020 | |
| 44 | Jackson Kowar# | 1131.2 | 2019-2025 | |
| 45 | Tyson Ross | 1123.2 | 2015-2024 | |
| 46 | Aaron Blair# | 1122.1 | 2020-2025 | |
| 47 | A.J. Cole# | 1121.0 | 2017-2024 | |
| 48 | Damien Magnifico# | 1105.1 | 2016-2025 | |
| 49 | Takahiro Norimoto# | 1101.2 | 2019-2025 | |
| 50 | Taijuan Walker# | 1100.1 | 2015-2025 | |
| 51 | Sandy Koufax# | 1097.1 | 1955-2025 | |
| 52 | Jake Arrieta | 1094.2 | 2015-2021 | |
| 53 | Matt Harvey | 1060.2 | 2015-2023 | |
| 54 | Ian Kennedy | 1060.1 | 2015-2022 | |
| 55 | Tyler Glasnow# | 1059.2 | 2017-2025 | |
| 56 | Julio Urias# | 1055.2 | 2018-2025 | |
| 57 | Hyun-jin Ryu# | 1052.2 | 2015-2025 | |
| 58 | Kevin Gausman# | 1047.1 | 2015-2021 | |
| 59 | Martin Perez# | 1042.1 | 2017-2024 | |
| 60 | Dallas Keuchel | 1034.2 | 2015-2023 | |
| 61 | Zach Petrick# | 1030.0 | 2018-2025 | |
| 62 | Carlos Martinez | 1023.0 | 2015-2023 | |
| 63 | Jose E. De Leon# | 1011.2 | 2017-2025 | |
| 64 | Cody Poteet# | 987.2 | 2019-2025 | |
| 65 | Matt Krook# | 952.1 | 2020-2025 | |
| 66 | Henry Owens | 949.2 | 2016-2022 | |
| 67 | Roger Clemens# | 948.0 | 2019-2025 | |
| 68 | Eduardo Rodriguez# | 944.1 | 2015-2025 | |
| 69 | Adam Wainwright | 915.2 | 2015-2019 | |
| 70 | Jameson Taillon# | 900.0 | 2016-2025 | |
| 71 | Alex Cobb | 881.1 | 2015-2019 | |
| 72 | Mike Leake | 875.2 | 2015-2021 | |
| 73 | Jose Quintana | 868.2 | 2015-2024 | |
| 74 | Juan Hillman# | 860.1 | 2020-2025 | |
| 75 | Wily Peralta | 837.0 | 2016-2020 | |
| 76 | Gerrit Cole | 821.1 | 2015-2025 | |
| 77 | Drew Pomeranz# | 816.2 | 2015-2025 | |
| 78 | Robby Stone# | 805.1 | 2020-2025 | |
| 79 | Nick Kingham# | 801.1 | 2017-2025 | |
| 80 | Adam Conley# | 796.0 | 2018-2024 | |
| 81 | Jarred Cosart | 783.1 | 2015-2020 | |
| 82 | Matt Boyd# | 782.1 | 2019-2025 | |
| 82 | Ricardo Sanchez# | 782.1 | 2021-2025 | |
| 84 | Jordan Walden# | 775.2 | 2015-2025 | |
| 85 | Alex Claudio# | 767.2 | 2015-2025 | |
| 86 | Johnny Cueto | 760.1 | 2015-2020 | |
| 87 | Shae Simmons# | 757.2 | 2015-2025 | |
| 88 | Zack Greinke | 756.1 | 2015-2018 | |
| 89 | Cody Allen# | 746.0 | 2015-2025 | |
| 90 | Carter Capps# | 729.0 | 2015-2025 | |
| 91 | Ryan Olson# | 728.2 | 2022-2025 | |
| 92 | Jarrod Parker | 723.0 | 2016-2021 | |
| 93 | Trevor Rosenthal# | 720.2 | 2015-2025 | |
| 94 | Ben Jordan# | 720.0 | 2021-2025 | |
| 95 | Kyle Crockett# | 708.0 | 2015-2025 | |
| 96 | Aroldis Chapman | 700.2 | 2015-2025 | |
| 97 | Matt Ramsey# | 691.1 | 2016-2025 | |
| 97 | Aaron Sanchez# | 691.1 | 2015-2018 | |
| 99 | Drew Storen# | 681.0 | 2015-2025 | |
| 100 | Paco Rodriguez# | 679.0 | 2015-2025 |
