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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Darren O'Day | 2015-2015 | 3 | 1 | .750 | 2.39 | 46 | 0 | 0 | 0 | 3 | 67.2 | 46 | 18 | 6 | 20 | 73 |
| Joe O'Donnell | 2022-2024 | 11 | 7 | .611 | 4.20 | 130 | 0 | 0 | 0 | 4 | 173.2 | 160 | 81 | 22 | 85 | 147 |
| Eric O'Flaherty | 2015-2021 | 19 | 14 | .576 | 2.83 | 351 | 0 | 0 | 0 | 21 | 315.0 | 278 | 99 | 30 | 112 | 315 |
| Ryan O'Rourke | 2016-2016 | 0 | 0 | .000 | 0.00 | 3 | 0 | 0 | 0 | 0 | 1.2 | 0 | 0 | 0 | 1 | 1 |
| Preston Oberling | 2024-2025 | 0 | 0 | .000 | 10.64 | 6 | 0 | 0 | 0 | 0 | 11.0 | 18 | 13 | 2 | 11 | 8 |
| Jake Odorizzi | 2015-2015 | 7 | 8 | .467 | 4.01 | 19 | 19 | 0 | 0 | 0 | 121.1 | 112 | 54 | 15 | 46 | 77 |
| Alexi Ogando | 2017-2017 | 0 | 1 | .000 | 4.74 | 45 | 0 | 0 | 0 | 0 | 62.2 | 67 | 33 | 9 | 31 | 43 |
| Steven Okert | 2018-2025 | 37 | 21 | .638 | 2.73 | 524 | 0 | 0 | 0 | 14 | 574.1 | 415 | 174 | 45 | 203 | 662 |
| Chris Okey | 2024-2025 | 0 | 0 | .000 | 40.50 | 3 | 0 | 0 | 0 | 0 | 0.2 | 3 | 3 | 2 | 2 | 0 |
| Jefferson Olacio | 2022-2025 | 5 | 5 | .500 | 5.93 | 27 | 6 | 0 | 0 | 0 | 71.1 | 66 | 47 | 8 | 56 | 61 |
| Andy Oliver | 2015-2017 | 1 | 1 | .500 | 1.25 | 18 | 0 | 0 | 0 | 1 | 21.2 | 15 | 3 | 1 | 8 | 16 |
| Hector Olivera | 2015-2021 | 0 | 0 | .000 | 0.00 | 1 | 0 | 0 | 0 | 0 | 0.1 | 0 | 0 | 0 | 0 | 0 |
| Ryan Olson | 2022-2025 | 42 | 37 | .532 | 3.63 | 119 | 119 | 7 | 3 | 0 | 728.2 | 642 | 294 | 83 | 281 | 666 |
| Logan Ondrusek | 2022-2022 | 0 | 1 | .000 | 7.50 | 8 | 0 | 0 | 0 | 0 | 6.0 | 5 | 5 | 1 | 2 | 5 |
| Jesús Ortíz | 2025-2025 | 0 | 0 | .000 | 0.00 | 1 | 0 | 0 | 0 | 0 | 1.0 | 1 | 0 | 0 | 0 | 1 |
| Joe Ortiz | 2015-2024 | 28 | 16 | .636 | 3.57 | 334 | 0 | 0 | 0 | 18 | 413.0 | 375 | 164 | 52 | 112 | 382 |
| Luis Ortiz | 2020-2024 | 20 | 9 | .690 | 4.88 | 193 | 2 | 0 | 0 | 8 | 352.1 | 337 | 191 | 69 | 153 | 330 |
| Roberto Osuna | 2016-2016 | 0 | 0 | .000 | 5.06 | 1 | 1 | 0 | 0 | 0 | 5.1 | 6 | 3 | 0 | 1 | 6 |
| Josh Outman | 2020-2023 | 10 | 9 | .526 | 3.73 | 209 | 0 | 0 | 0 | 4 | 241.0 | 197 | 100 | 17 | 111 | 222 |
| Henry Owens | 2016-2022 | 50 | 42 | .543 | 4.44 | 231 | 125 | 5 | 1 | 6 | 949.2 | 909 | 468 | 111 | 409 | 889 |
