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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Chris Sale# | 114 | 2015-2025 | |
| 2 | Sonny Gray# | 91 | 2015-2025 | |
| 3 | Matt Wisler# | 90 | 2016-2025 | |
| 4 | Cole Hamels | 78 | 2015-2022 | |
| 5 | Jose Fernandez# | 75 | 2015-2025 | |
| 6 | Jackson Kowar# | 70 | 2019-2025 | |
| 7 | Marcus Stroman# | 69 | 2015-2025 | |
| 8 | Anthony Molina# | 67 | 2022-2025 | |
| 9 | Noah Syndergaard# | 64 | 2015-2025 | |
| 10 | Aaron Blair# | 62 | 2020-2025 | |
| 11 | Jerad Eickhoff# | 56 | 2016-2025 | |
| 12 | Matt Krook# | 54 | 2020-2025 | |
| 13 | Jose Urena# | 51 | 2018-2025 | |
| 14 | Alex Claudio# | 50 | 2015-2025 | |
| 15 | Zack Greinke | 49 | 2015-2018 | |
| 15 | Kensaku Yamaguchi# | 49 | 2023-2025 | |
| 17 | Jordan Walden# | 48 | 2015-2025 | |
| 18 | Toby Kelly# | 46 | 2022-2025 | |
| 18 | Dan Stevens# | 46 | 2022-2025 | |
| 20 | Stephen Strasburg | 45 | 2015-2021 | |
| 21 | Kelvin Herrera | 44 | 2015-2025 | |
| 21 | Carlos Martinez | 44 | 2015-2023 | |
| 23 | Carter Capps# | 42 | 2015-2025 | |
| 24 | Jake Thompson# | 40 | 2018-2025 | |
| 25 | Sandy Koufax# | 39 | 1955-2025 | |
| 25 | Zach Petrick# | 39 | 2018-2025 | |
| 25 | Masahiro Tanaka | 39 | 2015-2024 | |
| 28 | Alex Wood# | 38 | 2015-2025 | |
| 29 | Takeru Kawakami# | 37 | 2023-2025 | |
| 30 | Ben Jordan# | 36 | 2021-2025 | |
| 30 | Noah Murdock# | 36 | 2023-2025 | |
| 30 | Alex Reyes# | 36 | 2020-2025 | |
| 33 | Parker McFadden# | 35 | 2021-2025 | |
| 33 | Robby Stone# | 35 | 2020-2025 | |
| 35 | Steven Okert# | 34 | 2018-2025 | |
| 36 | Jake Arrieta | 33 | 2015-2021 | |
| 36 | Jim Bartlett# | 33 | 2023-2025 | |
| 36 | Matt Harvey | 33 | 2015-2023 | |
| 39 | Aaron Nola# | 32 | 2015-2025 | |
| 40 | Grayson Garvin# | 31 | 2017-2025 | |
| 40 | Shelby Miller# | 31 | 2015-2025 | |
| 42 | C.J. Edwards | 30 | 2016-2024 | |
| 42 | Mike Morin# | 30 | 2016-2025 | |
| 44 | Sean Doolittle | 29 | 2015-2019 | |
| 44 | Tyler Glasnow# | 29 | 2017-2025 | |
| 44 | Carlos Rodon# | 29 | 2018-2025 | |
| 47 | Damien Magnifico# | 28 | 2016-2025 | |
| 48 | Shae Simmons# | 27 | 2015-2025 | |
| 49 | Al Alburquerque# | 26 | 2015-2025 | |
| 50 | Kolby Allard# | 25 | 2020-2025 | |
| 50 | Joe Gray# | 25 | 2023-2025 | |
| 50 | Phil Green# | 25 | 2022-2025 | |
| 53 | Jeurys Familia | 24 | 2015-2025 | |
| 53 | Jacob Lindgren# | 24 | 2016-2025 | |
| 53 | Mark Melancon | 24 | 2015-2023 | |
| 53 | Takahiro Norimoto# | 24 | 2019-2025 | |
| 53 | Drew Storen# | 24 | 2015-2025 | |
| 58 | Gerrit Cole | 23 | 2015-2025 | |
| 59 | Jacob deGrom | 22 | 2015-2022 | |
| 59 | Wally Higgins# | 22 | 2022-2025 | |
| 59 | Hunter Parsons# | 22 | 2022-2025 | |
| 59 | Evan Scribner | 22 | 2015-2021 | |
| 59 | Yordano Ventura# | 22 | 2016-2025 | |
| 64 | Dakota Bacus# | 21 | 2019-2025 | |
| 64 | Matt Boyd# | 21 | 2019-2025 | |
| 64 | Juan Hillman# | 21 | 2020-2025 | |
| 64 | Aaron Slegers# | 21 | 2019-2025 | |
| 64 | Ethan Small# | 21 | 2022-2025 | |
| 64 | Jesus Zambrano# | 21 | 2023-2025 | |
| 70 | Madison Bumgarner# | 20 | 2015-2022 | |
| 70 | Hagen Danner# | 20 | 2024-2025 | |
| 70 | Dailyn De Oleo# | 20 | 2023-2025 | |
| 70 | Charles King# | 20 | 2023-2025 | |
| 70 | Jong-your Lim# | 20 | 2019-2025 | |
| 70 | Boone Logan | 20 | 2015-2019 | |
| 70 | Bryan Price | 20 | 2015-2022 | |
| 70 | Max Scherzer | 20 | 2015-2021 | |
| 78 | Archie Bradley | 19 | 2015-2018 | |
| 78 | Heath Fillmyer# | 19 | 2018-2025 | |
| 80 | Roger Clemens# | 18 | 2019-2025 | |
| 80 | Felix Hernandez | 18 | 2015-2021 | |
| 80 | Cole Irvin# | 18 | 2020-2025 | |
| 80 | Shawn Kelley | 18 | 2015-2017 | |
| 80 | Evan Marshall# | 18 | 2015-2025 | |
| 80 | Drew Smyly | 18 | 2015-2023 | |
| 80 | Koji Uehara | 18 | 2015-2018 | |
| 80 | Daniel Winkler# | 18 | 2017-2025 | |
| 88 | Sean Burnett | 17 | 2015-2019 | |
| 88 | Justin De Fratus# | 17 | 2015-2024 | |
| 88 | Mayky Perez# | 17 | 2022-2025 | |
| 88 | Julio Teheran# | 17 | 2015-2025 | |
| 92 | Tim Collins | 16 | 2015-2022 | |
| 92 | Cal García# | 16 | 2025-2025 | |
| 92 | Eric Hankins# | 16 | 2020-2025 | |
| 92 | William Heflin# | 16 | 2025-2025 | |
| 92 | Reggie Lawson# | 16 | 2020-2025 | |
| 92 | Mike Minor | 16 | 2015-2017 | |
| 92 | Nick Pratto# | 16 | 2022-2025 | |
| 92 | Eric Robbins# | 16 | 2021-2025 | |
| 92 | Richard Rodriguez# | 16 | 2016-2025 |
