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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Chris Sale# | 2122 | 2015-2025 | |
| 2 | Shelby Miller# | 1930 | 2015-2025 | |
| 3 | Clayton Kershaw# | 1869 | 2015-2025 | |
| 4 | Jose Fernandez# | 1866 | 2015-2025 | |
| 5 | Julio Teheran# | 1859 | 2015-2025 | |
| 6 | Matt Wisler# | 1765 | 2016-2025 | |
| 7 | Noah Syndergaard# | 1724 | 2015-2025 | |
| 8 | Marcus Stroman# | 1659 | 2015-2025 | |
| 9 | Masahiro Tanaka | 1615 | 2015-2024 | |
| 10 | Alex Wood# | 1609 | 2015-2025 | |
| 11 | Sonny Gray# | 1604 | 2015-2025 | |
| 12 | Yordano Ventura# | 1534 | 2016-2025 | |
| 13 | Jeurys Familia | 1411 | 2015-2025 | |
| 14 | Carlos Rodon# | 1393 | 2018-2025 | |
| 15 | Zack Wheeler# | 1322 | 2015-2024 | |
| 16 | Grant Holmes# | 1275 | 2018-2025 | |
| 17 | Alex Reyes# | 1270 | 2020-2025 | |
| 18 | Jerad Eickhoff# | 1268 | 2016-2025 | |
| 19 | Michael Wacha# | 1259 | 2015-2025 | |
| 20 | Grayson Garvin# | 1210 | 2017-2025 | |
| 21 | Jackson Kowar# | 1208 | 2019-2025 | |
| 22 | Nate Karns | 1203 | 2015-2023 | |
| 23 | Stephen Strasburg | 1156 | 2015-2021 | |
| 24 | Madison Bumgarner# | 1149 | 2015-2022 | |
| 25 | Damien Magnifico# | 1127 | 2016-2025 | |
| 26 | Jacob deGrom | 1116 | 2015-2022 | |
| 27 | Corey Kluber | 1114 | 2015-2024 | |
| 28 | Cole Hamels | 1096 | 2015-2022 | |
| 29 | Sandy Koufax# | 1090 | 1955-2025 | |
| 30 | Julio Urias# | 1087 | 2018-2025 | |
| 31 | Max Scherzer | 1064 | 2015-2021 | |
| 32 | Kolby Allard# | 1053 | 2020-2025 | |
| 33 | Tyler Glasnow# | 1036 | 2017-2025 | |
| 34 | Cody Allen# | 1028 | 2015-2025 | |
| 35 | Shae Simmons# | 1012 | 2015-2025 | |
| 36 | Danny Duffy | 1000 | 2015-2023 | |
| 37 | Aroldis Chapman | 979 | 2015-2025 | |
| 38 | Aaron Nola# | 971 | 2015-2025 | |
| 39 | Jeff Samardzija | 970 | 2015-2021 | |
| 40 | Ken Giles# | 965 | 2015-2025 | |
| 41 | Carlos Martinez | 957 | 2015-2023 | |
| 42 | Garrett Richards | 945 | 2015-2022 | |
| 43 | Aaron Slegers# | 934 | 2019-2025 | |
| 44 | Tyson Ross | 922 | 2015-2024 | |
| 45 | Jordan Walden# | 910 | 2015-2025 | |
| 46 | Drew Smyly | 906 | 2015-2023 | |
| 47 | Aaron Blair# | 904 | 2020-2025 | |
| 47 | Roger Clemens# | 904 | 2019-2025 | |
| 49 | Jake Thompson# | 896 | 2018-2025 | |
| 50 | Taijuan Walker# | 892 | 2015-2025 | |
| 51 | Jose E. De Leon# | 889 | 2017-2025 | |
| 51 | Henry Owens | 889 | 2016-2022 | |
| 53 | Jose Urena# | 885 | 2018-2025 | |
| 54 | Chris Beck# | 883 | 2018-2025 | |
| 55 | Mike Foltynewicz# | 877 | 2015-2025 | |
| 55 | Ian Kennedy | 877 | 2015-2022 | |
| 57 | Cody Poteet# | 873 | 2019-2025 | |
| 58 | Paco Rodriguez# | 872 | 2015-2025 | |
| 59 | Alex Claudio# | 868 | 2015-2025 | |
| 60 | Kyle Crockett# | 864 | 2015-2025 | |
| 61 | Matt Harvey | 862 | 2015-2023 | |
| 62 | Jake Arrieta | 847 | 2015-2021 | |
| 63 | Felix Hernandez | 844 | 2015-2021 | |
| 64 | Jacob Lindgren# | 843 | 2016-2025 | |
| 65 | Carter Capps# | 837 | 2015-2025 | |
| 66 | Martin Perez# | 834 | 2017-2024 | |
| 67 | A.J. Cole# | 829 | 2017-2024 | |
| 68 | Justin Verlander | 827 | 2015-2020 | |
| 69 | Kenley Jansen | 814 | 2015-2023 | |
| 70 | David Price | 804 | 2015-2020 | |
| 71 | Adam Conley# | 798 | 2018-2024 | |
| 72 | Drew Pomeranz# | 797 | 2015-2025 | |
| 73 | Robby Stone# | 792 | 2020-2025 | |
| 74 | Jose Valdez# | 772 | 2015-2025 | |
| 75 | Hyun-jin Ryu# | 760 | 2015-2025 | |
| 76 | Eduardo Rodriguez# | 756 | 2015-2025 | |
| 77 | Kevin Gausman# | 737 | 2015-2021 | |
| 77 | Takahiro Norimoto# | 737 | 2019-2025 | |
| 79 | Kensaku Yamaguchi# | 733 | 2023-2025 | |
| 80 | Ricardo Sanchez# | 731 | 2021-2025 | |
| 81 | Zach Petrick# | 726 | 2018-2025 | |
| 82 | Trevor Rosenthal# | 725 | 2015-2025 | |
| 83 | Juan Hillman# | 717 | 2020-2025 | |
| 84 | Dallas Keuchel | 710 | 2015-2023 | |
| 85 | Al Alburquerque# | 706 | 2015-2025 | |
| 86 | Sam Tuivailala# | 704 | 2016-2025 | |
| 87 | Kyle Hendricks# | 702 | 2015-2025 | |
| 88 | Jordan Zimmermann | 695 | 2015-2020 | |
| 89 | Matt Krook# | 689 | 2020-2025 | |
| 90 | Kelvin Herrera | 684 | 2015-2025 | |
| 91 | Ben Jordan# | 677 | 2021-2025 | |
| 91 | Craig Kimbrel | 677 | 2015-2022 | |
| 93 | Wade Davis | 675 | 2015-2023 | |
| 94 | Jameson Taillon# | 672 | 2016-2025 | |
| 95 | Matt Ramsey# | 670 | 2016-2025 | |
| 96 | Gerrit Cole | 669 | 2015-2025 | |
| 97 | Ryan Olson# | 666 | 2022-2025 | |
| 98 | C.J. Edwards | 664 | 2016-2024 | |
| 99 | Steven Okert# | 662 | 2018-2025 | |
| 100 | Mike Morin# | 643 | 2016-2025 |
