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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Shelby Miller# | 299 | 2015-2025 | |
| 2 | Julio Teheran# | 282 | 2015-2025 | |
| 3 | Chris Sale# | 236 | 2015-2025 | |
| 4 | Corey Kluber | 234 | 2015-2024 | |
| 5 | Noah Syndergaard# | 233 | 2015-2025 | |
| 6 | Masahiro Tanaka | 224 | 2015-2024 | |
| 7 | Clayton Kershaw# | 223 | 2015-2025 | |
| 8 | Matt Wisler# | 220 | 2016-2025 | |
| 9 | Alex Wood# | 216 | 2015-2025 | |
| 10 | Zack Wheeler# | 206 | 2015-2024 | |
| 11 | Yordano Ventura# | 202 | 2016-2025 | |
| 12 | Marcus Stroman# | 196 | 2015-2025 | |
| 13 | Sonny Gray# | 187 | 2015-2025 | |
| 14 | Madison Bumgarner# | 186 | 2015-2022 | |
| 15 | Carlos Rodon# | 185 | 2018-2025 | |
| 16 | Aaron Nola# | 184 | 2015-2025 | |
| 17 | Jerad Eickhoff# | 182 | 2016-2025 | |
| 18 | A.J. Cole# | 174 | 2017-2024 | |
| 18 | Taijuan Walker# | 174 | 2015-2025 | |
| 20 | Jackson Kowar# | 171 | 2019-2025 | |
| 21 | Grant Holmes# | 168 | 2018-2025 | |
| 22 | Drew Smyly | 164 | 2015-2023 | |
| 23 | Jeff Samardzija | 158 | 2015-2021 | |
| 24 | Aaron Blair# | 157 | 2020-2025 | |
| 24 | Michael Wacha# | 157 | 2015-2025 | |
| 26 | Kolby Allard# | 156 | 2020-2025 | |
| 27 | Tyler Glasnow# | 155 | 2017-2025 | |
| 28 | Jacob deGrom | 154 | 2015-2022 | |
| 28 | Cole Hamels | 154 | 2015-2022 | |
| 30 | Danny Duffy | 150 | 2015-2023 | |
| 30 | Alex Reyes# | 150 | 2020-2025 | |
| 32 | Jeurys Familia | 149 | 2015-2025 | |
| 33 | Nate Karns | 148 | 2015-2023 | |
| 33 | Aaron Slegers# | 148 | 2019-2025 | |
| 35 | Jose Urena# | 145 | 2018-2025 | |
| 36 | Max Scherzer | 144 | 2015-2021 | |
| 37 | Stephen Strasburg | 143 | 2015-2021 | |
| 38 | Jose Fernandez# | 141 | 2015-2025 | |
| 38 | Tyson Ross | 141 | 2015-2024 | |
| 40 | Zach Petrick# | 139 | 2018-2025 | |
| 41 | Nick Kingham# | 138 | 2017-2025 | |
| 42 | Damien Magnifico# | 136 | 2016-2025 | |
| 42 | Julio Urias# | 136 | 2018-2025 | |
| 44 | Matt Krook# | 133 | 2020-2025 | |
| 45 | Jake Thompson# | 132 | 2018-2025 | |
| 46 | Cody Poteet# | 130 | 2019-2025 | |
| 46 | Jordan Zimmermann | 130 | 2015-2020 | |
| 48 | Juan Hillman# | 126 | 2020-2025 | |
| 48 | Ian Kennedy | 126 | 2015-2022 | |
| 50 | Grayson Garvin# | 125 | 2017-2025 | |
| 51 | Felix Hernandez | 123 | 2015-2021 | |
| 51 | Martin Perez# | 123 | 2017-2024 | |
| 51 | Garrett Richards | 123 | 2015-2022 | |
| 54 | Kevin Gausman# | 122 | 2015-2021 | |
| 55 | Mike Foltynewicz# | 120 | 2015-2025 | |
| 55 | David Price | 120 | 2015-2020 | |
| 57 | Matt Harvey | 118 | 2015-2023 | |
| 57 | Sandy Koufax# | 118 | 1955-2025 | |
| 59 | Hyun-jin Ryu# | 116 | 2015-2025 | |
| 59 | Ricardo Sanchez# | 116 | 2021-2025 | |
| 61 | Chris Beck# | 113 | 2018-2025 | |
| 61 | Roger Clemens# | 113 | 2019-2025 | |
| 61 | Takahiro Norimoto# | 113 | 2019-2025 | |
| 64 | Henry Owens | 111 | 2016-2022 | |
| 65 | Adam Conley# | 110 | 2018-2024 | |
| 66 | Justin Verlander | 109 | 2015-2020 | |
| 67 | Jose E. De Leon# | 108 | 2017-2025 | |
| 68 | Carlos Martinez | 101 | 2015-2023 | |
| 69 | Michael Matuella# | 100 | 2022-2025 | |
| 70 | Paco Rodriguez# | 99 | 2015-2025 | |
| 71 | Eduardo Rodriguez# | 98 | 2015-2025 | |
| 72 | Ashe Russell# | 95 | 2022-2025 | |
| 73 | Chandler Day# | 93 | 2021-2025 | |
| 74 | Jake Arrieta | 91 | 2015-2021 | |
| 74 | Ben Jordan# | 91 | 2021-2025 | |
| 76 | Nick Pivetta# | 90 | 2022-2025 | |
| 77 | Jesus Zambrano# | 89 | 2023-2025 | |
| 78 | Kyle Serrano# | 88 | 2022-2025 | |
| 79 | Hunter Harvey# | 87 | 2018-2025 | |
| 79 | Reggie Lawson# | 87 | 2020-2025 | |
| 81 | Trevor Rosenthal# | 86 | 2015-2025 | |
| 82 | Ian Anderson# | 85 | 2022-2025 | |
| 83 | Cole Irvin# | 84 | 2020-2025 | |
| 84 | Jim Bartlett# | 83 | 2023-2025 | |
| 84 | Gerrit Cole | 83 | 2015-2025 | |
| 84 | Ryan Olson# | 83 | 2022-2025 | |
| 84 | Wily Peralta | 83 | 2016-2020 | |
| 84 | Matt Ramsey# | 83 | 2016-2025 | |
| 89 | Alex Cobb | 82 | 2015-2019 | |
| 89 | Robby Stone# | 82 | 2020-2025 | |
| 89 | Jameson Taillon# | 82 | 2016-2025 | |
| 92 | Drew Pomeranz# | 81 | 2015-2025 | |
| 92 | Adam Wainwright | 81 | 2015-2019 | |
| 94 | Trevor Bauer | 80 | 2015-2020 | |
| 94 | Dallas Keuchel | 80 | 2015-2023 | |
| 94 | Anthony Molina# | 80 | 2022-2025 | |
| 94 | Shae Simmons# | 80 | 2015-2025 | |
| 98 | Jordan Hicks# | 79 | 2023-2025 | |
| 99 | Matt Boyd# | 78 | 2019-2025 | |
| 99 | Kyle Hendricks# | 78 | 2015-2025 |
